Carboxylic acids as a traceless activation group for conjugate additions: a three-step synthesis of (±)-pregabalin. Journal of the American Chemical Society. 136: 10886-9. PMID 25032785 DOI: 10.1021/ja505964r : 1: 2014: Noble A, MacMillan DW. Photoredox α-vinylation of α-amino acids and N-aryl amines.

Sulfonyl as a Traceless Activation Group for Enantioselective Mannich Reaction Catalyzed by Thiourea to Access Chiral β-Aminophosphonates Yungui Peng* Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. of China Email: pengyungui@hotmail.com Mar 09, 2020 · We reasoned appending a vinyl group to the carbene C., Zuo, Z. & MacMillan, D. W. C. Carboxylic acids as a traceless activation group for conjugate additions: a three-step synthesis of A new neutral silicon-based traceless activation group (TAG) for visible-light photoredox-catalyzed hydroalkoxymethylation of alkenes is presented. This reaction involves in-situ-generated alkoxymethyl radical via single electron oxidation (SET) of α-TMS-substituted ethers, followed by subsequent conjugate addition to activated alkenes. Dec 18, 2014 · Chu L, Ohta C, Zuo Z, MacMillan DWC. Carboxylic acids as a traceless activation group for conjugate additions: a three-step synthesis of (±)-pregabalin. J. Am. Chem. Soc. 2014; 136:10886–10889. [PMC free article]

Aug 06, 2014 · Over the past four decades, significant advances have been made in the development of traceless activation groups (TAGs) such as cuprates, boronic acids, halides, and Grignard reagents that enable a broad range of organic structures to participate as nucleophiles or donor components in this 1,4-coupling pathway. 2,3 Expanding upon this theme, we recently questioned whether simple and abundant carboxylic acids might be generically 5 employed as a traceless activation group for radical 1,4

Jun 01, 2004 · Designing a new anchoring group can be essential for synthesis success, especially for small molecules on solid supports. Many novel linkers have recently been developed. Traceless linkers can be excised efficiently and quantitatively when desired while leaving behind no trace of the solid-phase synthesis.

A new neutral silicon-based traceless activation group (TAG) for visible-light photoredox-catalyzed hydroalkoxymethylation of alkenes is presented. This reaction involves in-situ-generated alkoxymethyl radical via single electron oxidation (SET) of α-TMS-substituted ethers, followed by subsequent conjugate addition to activated alkenes.

Jan 01, 2015 · Carboxylic acids as a traceless activation group for conjugate additions: a three-step synthesis of (±)-pregabalin. Aug 6, 2014 · Journal of the American Chemical Society 14.70 # 1 Lingling Chu H-Index: 21 The direct application of carboxylic acids as a traceless activation group for radical Michael additions has been accomplished via visible light-mediated photoredox catalysis. Photon-induced The cyano group was used as a traceless activation group for the [3+2] cycloaddition of azomethine ylides in a two-step process, thereby providing a highly effective approach to 5-unsubstituted pyrrolidines. Full Text Carboxylic Acids as A Traceless Activation Group for Conjugate Additions: A Three-Step Synthesis of (±)-Pregabalin by Chu, Lingling and Ohta, Chisa and Zuo, Zhiwei and MacMillan, David W. C Mar 15, 2018 · A photochemical decarboxylative cross-coupling reaction of aryl acetic acids with 1,4-dicyanobenzene (1,4-DCB) was developed. Under UV light irradiation, the inexpensive aryl acetic acids coupled with 1,4-DCB, isocyanates and alkene derivatives through decarboxylation which led to the corresponding diarylmethanes, amides and alkene derivatives were obtained in moderate to good yields under Enter search terms. Keep search filters New search. Advanced search Jul 17, 2020 · Self-assembled nanostructures are highly promising for controlled delivery of therapeutic and diagnostic agents. However, for conventional drug delive…